Reevaluating Nonoperative Management for Pediatric Uncomplicated Acute Appendicitis: A Systematic Review and Meta-Analysis
JAMA Pediatrics
•
October 05, 2025
Appendectomy outperforms antibiotics for pediatric appendicitis
In children with uncomplicated appendicitis, antibiotic-only treatment led to more failures and major complications within one year than appendectomy. *Systematic review and meta-analysis of randomized trials; Level 1a (OCEBM).
- Level of evidence
- Level 1a (OCEBM)
- DocG quality score
- 5.6 / 10
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