Effect of Interventions Aimed at Reducing or Modifying Saturated Fat Intake on Cholesterol, Mortality, and Major Cardiovascular Events: A Risk-Stratified Systematic Review of Randomized Trials
Annals of Internal Medicine
•
December 16, 2025
High-risk patients benefit most from saturated fat changes
Reducing saturated fat shows little benefit in low-risk adults, but may reduce deaths and heart attacks in high-risk adults, especially when replaced with polyunsaturated fat. *Systematic review of randomized trials; Level 1a (OCEBM).
- Level of evidence
- Level 1a (OCEBM)
- DocG quality score
- 7.0 / 10
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