High-Dose vs Standard-Dose Influenza Vaccine in Older Adults With Diabetes: A Secondary Analysis of the DANFLU-2 Randomized Clinical Trial
JAMA Internal Medicine
•
January 12, 2026
High-dose flu vaccine reduces hospitalizations
In adults 65 years or older, a high-dose influenza vaccine modestly reduced several hospitalization outcomes compared with a standard-dose vaccine, with similar benefit in people with and without diabetes. *Pragmatic open-label randomized clinical trial (secondary analysis); Level 1b.
- Level of evidence
- Level 1b
- DocG quality score
- 7.5 / 10
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