Transdermal Estradiol Patches in Locally Advanced Prostate Cancer
The New England Journal of Medicine
•
March 25, 2026
Estradiol patches match standard hormone injections
In men with locally advanced prostate cancer, estradiol skin patches were as effective as standard hormone injections for preventing spread or death at 3 years, with fewer hot flashes but more breast swelling. *Randomized noninferiority trial; Level 1b (OCEBM).
- Level of evidence
- Level 1b (OCEBM)
- DocG quality score
- 5.8 / 10
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