Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease
The New England Journal of Medicine
•
April 09, 2026
Lower bad-cholesterol targets reduce cardiovascular events
In patients with established atherosclerotic cardiovascular disease, aiming for low-density lipoprotein cholesterol under 55 mg/dL lowered 3-year cardiovascular events versus under 70 mg/dL, with similar overall safety. *Open-label randomized superiority trial; Level 1b (OCEBM).
- Level of evidence
- Level 1b (OCEBM)
- DocG quality score
- 6.8 / 10
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