Deprescribing Intervention and Reduction of Proton Pump Inhibitor Use in Primary Care: A Cluster Randomized Clinical Trial
JAMA Internal Medicine
•
April 13, 2026
Patient mailings reduce long-term proton pump inhibitor use
Mailing education to patients plus guidance to clinicians roughly doubled meaningful dose reduction of long-term proton pump inhibitor use without worsening reflux symptoms. *Pragmatic cluster randomized clinical trial; Level 1b (OCEBM).
- Level of evidence
- Level 1b (OCEBM)
- DocG quality score
- 7.1 / 10
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