Amoxicillin-Clavulanate vs Amoxicillin for Acute Sinusitis in Adults
JAMA
•
April 18, 2026
Amoxicillin is usually enough for sinusitis
In adults with uncomplicated acute sinusitis, amoxicillin-clavulanate did not reduce treatment failure but increased later yeast and Clostridioides difficile infections. *Retrospective matched cohort study; Level 2b (Oxford).
- Level of evidence
- Level 2b (Oxford)
- DocG quality score
- 7.1 / 10
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