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Benefits and Harms of Pharmacologic Treatments in Adults With Overweight or Obesity: A Living Systematic Review and Network Meta-analysis for the American College of Physicians

Semaglutide and tirzepatide lead weight-loss drugs

Damen JAA, Idema DL, Vernooij RWM, et al. Benefits and Harms of Pharmacologic Treatments in Adults With Overweight or Obesity. Ann Intern Med . 2026;179:1140-1155.

Level of evidence
Level 1a
DocG quality score
7.1 / 10

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