Intravenous Thrombolysis Beyond the Conventional Time Window for Acute Ischemic Stroke: A Systematic Review and Meta-Analysis
JAMA Network Open
•
August 06, 2026
Late thrombolysis benefits selected stroke patients
In imaging-selected acute ischemic stroke, intravenous clot-busting therapy after 4.5 hours improved 90-day function but increased symptomatic brain bleeding. *Systematic review and meta-analysis of randomized trials; Level 1a.
- Level of evidence
- Level 1a
- DocG quality score
- 8.3 / 10
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