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Top Internal Medicine Research Papers
1.
8.2
Safety of Age-Adjusted and Clinical Probability-Adjusted D-dimer Cut-offs in Suspected Pulmonary Embolism: A Systematic Review and Meta-Analysis.
Overall: A large synthesis of prospective management studies supports adaptive D-dimer thresholds as a practical way to reduce chest imaging while maintaining very low rates of missed clinically important thromboembolism.
2.
8.1
Effectiveness of Nirmatrelvir/Ritonavir for Outpatients in the Era of Omicron, Vaccination, and Previous Infection: A Meta-analysis.
Overall: This large contemporary meta-analysis supports meaningful reductions in hospitalization and death with nirmatrelvir-ritonavir among higher-risk outpatients, although reliance on observational studies and absent harm data limit certainty.
3.
7.8
A meta-analysis of the long-term effects of antihypertensive therapy on the risk of major cardiovascular disease across 51 randomized trials.
Overall: A large and precise randomized-trial meta-analysis demonstrates early, modest reductions in major cardiovascular events from blood-pressure lowering, with high primary-care relevance but limited novelty and no reported harms.
4.
7.5
Obexelimab for the Treatment of IgG4-Related Disease.
Overall: A rigorous phase 3 trial found a large reduction in clinically important flares and glucocorticoid exposure with manageable reported harms, offering practice-changing evidence despite weekly biologic-treatment burden.
5.
7.3
Effect of timing of morning blood draws on sleep quantity and quality in hospitalized patients.
Overall: Delaying routine morning blood draws produced meaningful improvements in hospitalized patients’ sleep with minimal implementation burden, but the nonrandomized design and reliance on self-report reduce certainty.
6.
7.1
Tobacco Treatment in the Inpatient Setting: An American College of Chest Physicians Clinical Practice Guideline.
Overall: This methodologically rigorous and clinically actionable US guideline addresses important outcomes and a common care gap, but absent quantitative benefit-harm estimates and the lack of high-certainty inpatient-specific evidence limit confidence in its net benefit.
7.
7.1
Oral Nirmatrelvir-Ritonavir for Covid-19 in Higher-Risk Outpatients.
Overall: These directly relevant randomized outpatient trials found no reduction in hospitalization or death from nirmatrelvir-ritonavir among vaccinated higher-risk adults despite lowering viral load.
8.
6.8
Sodium Bicarbonate for In-Hospital Cardiac Arrest: A Randomized Clinical Trial.
Overall: A strong multicenter blinded trial found no meaningful benefit and more metabolic adverse effects, supporting discontinuation of routine sodium bicarbonate during in-hospital cardiac arrest.
9.
6.8
Recurrent venous thromboembolism and bleeding during anticoagulation in patients with deep-vein thrombosis treated with vitamin K antagonists or direct oral anticoagulants: insights from the RIETE registry.
Overall: A large real-world registry supports clinically important benefits and a tradeoff with more non-major bleeding, but residual confounding, missing absolute effects, and confirmation of established practice limit its impact.
10.
6.7
Risk factors for hospital admission and mortality in patients with influenza virus infection: a systematic review and meta-analysis.
Overall: This large, rigorous observational evidence synthesis identifies clinically important predictors of influenza admission and mortality, but lacks absolute risks and evidence that acting on these associations improves outcomes.
Score Guide:
9-10 Exceptional
7-8 Strong
5-6 Moderate
3-4 Weak
1-2 Poor
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