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Top Surgery (Other) Research Papers
1.
7.6
Sirolimus-Coated Balloon Angioplasty for Infrainguinal Artery Disease.
Overall: This well-conducted randomized trial found a clinically meaningful reduction in repeat limb procedures or major amputation without an evident one-year safety penalty, supporting potential adoption during infrainguinal angioplasty.
2.
7.2
Cold and Room-Temperature Platelets in Cardiac Surgery: The CHIPS Randomized Clinical Trial.
Overall: A large, well-conducted randomized trial supports substantially longer cold storage without reduced hemostatic efficacy, although no patient-level superiority was shown and increased reexploration requires attention.
3.
7.2
Safety of routine antimicrobial prophylaxis for surgery (SAPPHIRE): a prospective multi-centre cohort study.
Overall: This large prospective cohort links additional perioperative antimicrobial doses to more adverse effects without fewer infections, but residual confounding prevents firm causal conclusions.
4.
7.2
Cost-Effectiveness of Endovascular vs Open Surgery for Chronic Limb-Threatening Ischemia.
Overall: This rigorous trial-based US economic evaluation favors bypass surgery on cost and effectiveness, but its modest projected health advantage and remaining subgroup uncertainty temper its immediate impact.
5.
7.2
Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results of an international, multicentre, open-label, parallel-group, randomised, phase 2/3 trial.
Overall: This randomized multicentre trial shows a substantial early organ-preservation advantage for LCCRT, but definitive functional and oncological outcomes require longer follow-up.
6.
7.0
Bioengineered acellular tissue engineered vessels versus autogenous fistulae for haemodialysis access: a multicentre, randomised, controlled, phase 3 trial.
Overall: This well-conducted US randomised trial found clinically meaningful improvements in dialysis-access function with ATEV, but more interventions, limited follow-up, and unresolved implementation issues reduce its overall impact.
7.
6.9
Bempedoic Acid and First and Recurrent Limb Outcomes in Statin-Intolerant Patients With Peripheral Artery Disease: Insights From the CLEAR Outcomes Trial.
Overall: A credible randomized-trial subgroup analysis shows a meaningful reduction in clinically important limb events with an easily administered therapy, but modest absolute benefit, limited event counts, and unreported harms temper its impact.
8.
6.7
Semaglutide versus placebo in individuals with poor weight loss after bariatric surgery: a double-blinded, randomized, placebo-controlled trial.
Overall: This rigorous but small trial found substantial weight loss with semaglutide in a specialized post-bariatric population, with promising clinical relevance tempered by limited patient-outcome data, safety events, and implementation barriers.
9.
6.6
Middle Meningeal Artery Embolization With n-Butyl Cyanoacrylate in Patients With Chronic Subdural Hematoma: A Randomized Clinical Trial.
Overall: This multicenter randomized trial found a large reduction in recurrence or reoperation with adjunctive MMAE, but missing outcome data, a partly radiographic endpoint, procedural burden, and specialized resource requirements limit certainty and broad implementation.
10.
6.5
Transanal irrigation for low anterior resection syndrome: a systematic review and narrative synthesis with emphasis on nurse-led implementation.
Overall: This review reports substantial patient-important symptom improvement and few harms, but its small, heterogeneous evidence base and short follow-up limit certainty and immediate practice-changing authority.
Score Guide:
9-10 Exceptional
7-8 Strong
5-6 Moderate
3-4 Weak
1-2 Poor
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